1-(2,3-Dihydro-1H-inden-5-yl)ethan-1-one → 2,3-dihydro-1H-indene-5-carboxylic acid

HRID 869852

反応式

HRID 869852 の反応式
Cl[O-].[Na+].[CH2:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13](=[O:15])C)[CH:11]=2)[CH2:6][CH2:5]1.C([O-])(O)=[O:17].[Na+]>>[CH2:6]1[C:7]2[C:12](=[CH:11][C:10]([C:13]([OH:15])=[O:17])=[CH:9][CH:8]=2)[CH2:4][CH2:5]1

参加物

4

反応物 3

HCID 2339761-(2,3-Dihydro-1H-inden-5-yl)ethan-1-oneHCID 516892Sodium BicarbonateHCID 23665760Sodium Hypochlorite

生成物 1

HCID 2328412,3-dihydro-1H-indene-5-carboxylic acid収率 99%

実験手順

To a stirred aqueous sodium hypochlorite solution (2230 ml, 1.80 mmol, 6□) at 55□ was added 1-(2,3-dihydro-1H-inden-6-yl)ethanone (120.0 g, 0.75 mol) and the mixture was stirred at 55□ for 2 h. After cooling to room temperature, saturated NaHCO3 solution was added until the solution became clear. The produced precipitate was filtered, washed several times with water and dried to afford the desired product (120.0 g, 99%). 1H NMR (CDCl3, 300 MHz) δ 2.07-2.17 (m, 2H), 2.96 (t, J=7.5 Hz, 4H), 7.30 (d, J=7.8, 1H,), 7.91 (d, J=7.8, 1H), 7.96 (s, 1H).

後処理

  1. filtrationThe produced precipitate was filtered
  2. washwashed several times with water
  3. customdried

出典と根拠

ORDレコード
ord-b55a6a3c2a5a49118e82c2685b28bfbe
出典データセット
uspto-grants-2015_03
特許番号
US08969386B2

関連ノート

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