化工社化工社 化学情報印刷レポート · 研究参考用
Water → 4-Chloro-6-(4-fluorophenyl)-2-methylpyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | HCID 178418772 | HCID 178418772 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-Chloro-6-(4-fluorophenyl)-2-methylpyrimidine | HCID 15870142 | 97% |
反応手順
13.8 kg of 4-(4-fluorophenyl)-6-hydroxy-2-methylpyrimidine and 11.5 kg of phosphorus oxychloride were refluxed in acetonitrile, and stirred for 4 hours. The reaction solution was combined with water, and the precipitated crystal was separated, and the resultant crystal was washed and dried to obtain 14.6 kg of the target compound as a pale yellow crystal.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091206B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-566f636694d74e4bbcaca894597ef315 |
| 出典メモ | uspto-grants-2006_08 |