Diethyl (4-aminophenyl)phosphonate → 4-(3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl-sulfonamido)phenylphosphonic acid

HRID 870132ノート

反応式

HRID 870132 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:15]=[C:16]([S:20]([NH:23][CH2:24][CH2:25]P(=O)(O)O)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1.NC1C=[CH:35][C:34]([P:37](=[O:44])([O:41]CC)[O:38]CC)=[CH:33][CH:32]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:15]=[C:16]([S:20]([NH:23][C:24]2[CH:32]=[CH:33][C:34]([P:37](=[O:38])([OH:44])[OH:41])=[CH:35][CH:25]=2)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1

参加物

3

反応物 2

HCID 273213Diethyl (4-aminophenyl)phosphonate2 回HCID 674602442-(3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethylphosphonic acid

生成物 1

HCID 674594274-(3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl-sulfonamido)phenylphosphonic acid

実験手順

Compound 2 was prepared in an analogous manner to that of Compound 1 using diethyl 4-aminophenylphosphonate (Intermediate 2.2) as the amine. 1H-NMR (300 MHz, CD3OD, ppm): 7.86 (d, 1H), 7.69 (m, 3H), 7.55 (m, 3H), 7.21 (m, 2H), 6.73 (s, 1H), 4.70 (m, 2H), 4.48 (d, 1H), 3.79 (m, 1H), 3.46 (m, 1H), 3.09 (s, 3H). MS (ES, m/z): 527 [M+H]+.

出典と根拠

ORDレコード
ord-b7bbb492b3474664985dec77a8bb00d5
出典データセット
uspto-grants-2015_03
特許番号
US08969377B2

反応ノート

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