4-Bromophenacyl bromide → 1-(4-Bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanone

HRID 870145

反応式

HRID 870145 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=[O:4].C(N(CC)CC)C.[Cl:19][C:20]1[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:21]=1[CH2:27][NH:28][CH3:29]>O1CCOCC1>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][N:28]([CH2:27][C:21]2[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:20]=2[Cl:19])[CH3:29])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 74544-Bromophenacyl bromideHCID 8471TriethylamineHCID 485424Benzenemethanamine, 2,4-dichloro-N-methyl-

生成物 1

HCID 223868281-(4-Bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanone

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
25 °C

実験手順

Into a 250-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a solution of 2-bromo-1-(4-bromophenyl)ethanone (9.3 g, 33.45 mmol, 1.00 equiv) in dioxane (100 mL), triethylamine (5.0 g, 1.50 equiv), and (2,4-dichlorophenyl)-N-methylmethanamine (6.4 g, 33.68 mmol, 1.00 equiv). The resulting solution was stirred for 2 h at 25° C. The solids were filtered out. The filtrate was used for next step directly.

後処理

  1. customInto a 250-mL 3-necked round-bottom flask purged
  2. temperaturemaintained with an inert atmosphere of nitrogen
  3. filtrationThe solids were filtered out

出典と根拠

ORDレコード
ord-8810e10074554d5fa7dd0a3d3a8fcd97
出典データセット
uspto-grants-2015_03
特許番号
US08969377B2

関連ノート

読み込み中…