Hydrochloric Acid → 806595-48-2

HRID 870572ノート

反応式

HRID 870572 の反応式
Cl.[CH3:2][O:3][C:4](=[O:11])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]#[N:10].[CH2:12]([O:14]CC)C>CO>[NH:10]=[C:9]([O:14][CH3:12])[CH2:8][CH2:7][CH2:6][CH2:5][C:4]([O:3][CH3:2])=[O:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl Ether2 回HCID 554130Methyl 5-cyanopentanoate

生成物 1

HCID 23189824806595-48-2収率 83%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Bubble hydrogen chloride (g) through a 0° C. solution of 5-cyano-pentanoic acid methyl ester (3.0 mL; 1.00 equiv; 22.02 mmoles) in methanol (5 mL), and ethyl ether (10 mL) for 1 hour. Allow the solution to warm to room temperature then add 50 mL ethyl ether, stir vigorously for 15 minutes, then filter and collect the resulting precipitate. Wash the solid with ethyl ether to afford methyl 6-imino-6-methoxy-hexanoate (3.82 g; 83%): 1H NMR (DMSO) δ 1.47-1.62 (m, 4H), 2.31 (t, 2H), 2.59 (t, 2H), 3.56 (s, 3H), 4.03 (s, 3H).

後処理

  1. filtrationfilter
  2. customcollect the resulting precipitate
  3. washWash the solid with ethyl ether

出典と根拠

ORDレコード
ord-c98fa7a79c2c40388b3ab71576959e67
出典データセット
uspto-grants-2015_03
特許番号
US08969555B2

反応ノート

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