Bromine → (S)-tert-Butyl(1-(4-(3-bromoimidazo[1,2-b]pyridazin-6-yl)piperazin-1-yl)-4-methyl-1-oxopentan-2yl)carbamate

HRID 870783ノート

反応式

HRID 870783 の反応式
[C:1]([O:5][C:6](=[O:30])[NH:7][C@@H:8]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:18]=[CH:19][C:20]3[N:21]([CH:23]=[CH:24][N:25]=3)[N:22]=2)[CH2:13][CH2:12]1)=[O:10])([CH3:4])([CH3:3])[CH3:2].[Br:31]Br>CC(O)=O>[C:1]([O:5][C:6](=[O:30])[NH:7][C@@H:8]([CH2:26][CH:27]([CH3:28])[CH3:29])[C:9]([N:11]1[CH2:12][CH2:13][N:14]([C:17]2[CH:18]=[CH:19][C:20]3[N:21]([C:23]([Br:31])=[CH:24][N:25]=3)[N:22]=2)[CH2:15][CH2:16]1)=[O:10])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 24408BromineHCID 86696490(S)-tert-Butyl (1-(4-(imidazo[1,2-b]pyridazin-6-yl)piperazin-1-yl)-4-methyl-1-oxopentan-2-yl)carbamate

生成物 1

HCID 89805288(S)-tert-Butyl(1-(4-(3-bromoimidazo[1,2-b]pyridazin-6-yl)piperazin-1-yl)-4-methyl-1-oxopentan-2yl)carbamate

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To 104 mg (0.25 mmol) of (S)-tert-butyl(1-(4-(imidazo[1,2-b]pyridazin-6-yl)piperazin-1-yl)-4-methyl-1-oxopentan-2-yl)carbamate dissolved in 5 mL of AcOH was added bromine (48 mg, 0.3 mmol) and the resulting mixture was stirred at room temperature. After 0.25 hr, the reaction was done, and concentrated by rotavap and then by high vacuum pump to obtain 139 mg (100% yield) of mono-acetic acid salt of the desired product.

後処理

  1. concentrationconcentrated by rotavap

出典と根拠

ORDレコード
ord-7191e60995214bea91a280d61be7c6ea
出典データセット
uspto-grants-2015_03
特許番号
US08969565B2

反応ノート

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