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2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid → Tert-butyl 4-(4-(2-(pyridin-4-yl)thiazole-4-carboxamido)isothiazol-5-yl)piperazine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Pyridin-4-yl)-1,3-thiazole-4-carboxylic acid | HCID 716091 | — |
| 反応物 | 2-(2,6-Difluorophenyl)-1,3-thiazole-4-carboxylic acid | HCID 24278454 | — |
| 反応物 | Tert-butyl 4-(4-aminoisothiazol-5-yl)piperazine-1-carboxylate | HCID 86720862 | — |
| 生成物 | Tert-butyl 4-(4-(2-(pyridin-4-yl)thiazole-4-carboxamido)isothiazol-5-yl)piperazine-1-carboxylate | HCID 86720861 | 89.3% |
反応手順
Following the procedure described in Step (3) of Example 6, and substituting Compounds 2E and 6D8 with 2-(pyridin-4-yl)thiazole-4-carboxylic acid (19E) (58 mg, 0.28 mmol) and tert-butyl 4-(4-aminoisothiazol-5-yl)piperazine-1-carboxylate (31D3) (80 mg, 0.28 mmol) respectively, Compound 31A (120 mg, 0.25 mmol) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08969584B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-74bcf30c1b6648f49792e395565db9c8 |
| 出典メモ | uspto-grants-2015_03 |