4-(3,4-Dichlorophenyl)-2-hydrazinylthiazole → HCID 89676234、化合物

HRID 871066

反応式

HRID 871066 の反応式
[N:1]([CH2:4][C:5](=O)[C:6]([OH:8])=[O:7])=[N+:2]=[N-:3].[Cl:10][C:11]1[CH:12]=[C:13]([C:18]2[N:19]=[C:20]([NH:23][NH2:24])[S:21][CH:22]=2)[CH:14]=[CH:15][C:16]=1[Cl:17]>C(O)(=O)C.C(O)C>[N:1]([CH2:4]/[C:5](=[N:24]\[NH:23][C:20]1[S:21][CH:22]=[C:18]([C:13]2[CH:14]=[CH:15][C:16]([Cl:17])=[C:11]([Cl:10])[CH:12]=2)[N:19]=1)/[C:6]([OH:8])=[O:7])=[N+:2]=[N-:3]

参加物

5

反応物 2

HCID 71740714-(3,4-Dichlorophenyl)-2-hydrazinylthiazoleHCID 866899443-Azido-2-oxopropanoic acid

生成物 1

HCID 89676234HCID 89676234、化合物

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 702Ethanol溶媒

実験手順

KY-757 3-azido-2-oxopropanoic acid, KY-740 (100 mg, 0.77 mmol) in 5% acetic acid 162 ul was added in to solution of [4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-hydrazine (0.2 gr, 0.77 mmol) in ethanol 2 ml. the reaction mixture was stirred at room temperature for 5 h. and then cooled to room temperature. The yellow solid was precipitated out, filtered and washed by water. Yield 0.1 gr (35%). MS+(ESI) m/z 371.91, calcd mass 371.2.

後処理

  1. temperaturecooled to room temperature
  2. customThe yellow solid was precipitated out
  3. filtrationfiltered
  4. washwashed by water

出典と根拠

ORDレコード
ord-7a3cb8f7557c4797b3675cf823e12ec2
出典データセット
uspto-grants-2015_03
特許番号
US08969573B2

関連ノート

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