Triethylamine → 4-Ethylamino-2-methylthio-5-pyrimidinecarboxylic acid fluoride

反応式

[CH2:1]([NH:3][C:4]1[C:9]([C:10](O)=[O:11])=[CH:8][N:7]=[C:6]([S:13][CH3:14])[N:5]=1)[CH3:2].C(N(CC)CC)C.N1C(F)=NC(F)=NC=1[F:24]>C(Cl)Cl>[CH2:1]([NH:3][C:4]1[C:9]([C:10]([F:24])=[O:11])=[CH:8][N:7]=[C:6]([S:13][CH3:14])[N:5]=1)[CH3:2]

参加物

実験手順

To a solution containing 3.0 g (14.0 mmol) of 4-ethylamino-2-methylthio-5-pyrimidinecarboxylic acid and 2.1 mL (15.0 mmol) of triethylamine in 50 mL of CH2Cl2 are added 2.3 mL (28.0 mmol) of cyanuric fluoride. The mixture is stirred for 3 hours and the solution is diluted with 250 mL of CH2Cl2 and 75 mL of ice-cold water. After separation of the phases by settling, the organic phase is washed with 75 mL of ice-cold water and dried over MgSO4. The solvent is then evaporated off under reduced pressure. 3.0 g of expected product are obtained in the form of a greenish gum. The yield is quantitative.