Hydrochloric Acid → Hydrochloric Acid

HRID 871949ノート

反応式

HRID 871949 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]2[S:15][CH:16]=[C:17]([CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([N:27]4[CH:31]=[N:30][N:29]=[N:28]4)=[CH:23][CH:22]=3)[N:18]=2)[CH2:9]1)=O)(C)(C)C.[ClH:32]>ClCCl.CO.O1CCOCC1>[N:27]1([C:24]2[CH:23]=[CH:22][C:21]([O:20][CH2:19][C:17]3[N:18]=[C:14]([CH:10]4[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]4)[S:15][CH:16]=3)=[CH:26][CH:25]=2)[CH:31]=[N:30][N:29]=[N:28]1.[ClH:32]

参加物

7

反応物 2

HCID 313Hydrochloric AcidHCID 57986828HCID 57986828、化合物

生成物 2

HCID 313Hydrochloric AcidHCID 57473380HCID 57473380、化合物

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of 3-[4-(4-Tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (500 mg, 1.13 mmol) in dichloromethane (10 mL) and methanol (2 mL) were treated with 2 mL of 4N HCl in dioxane. The resulting solution was stirred at room temperature for 30 minutes. The solvents were removed in vacuo to afford the desired product as an HCl salt.

後処理

  1. customThe solvents were removed in vacuo

出典と根拠

ORDレコード
ord-909c460ad8f24b839471708972b6253e
出典データセット
uspto-grants-2015_03
特許番号
US08975258B2

反応ノート

読み込み中…