Cyclohexanecarboxylic acid → N-(1-propyl-1H-tetrazol-5-yl)cyclohexane-carboxamide

反応式

[CH:1]1([C:7]([OH:9])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:10]([N:13]1[C:17]([NH2:18])=[N:16][N:15]=[N:14]1)[CH2:11][CH3:12]>>[CH2:10]([N:13]1[C:17]([NH:18][C:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)=[O:9])=[N:16][N:15]=[N:14]1)[CH2:11][CH3:12]

参加物

反応物 2

HCID 7413Cyclohexanecarboxylic acid

HCID 2206221-propyl-1H-tetrazol-5-amine

生成物 1

HCID 90407822N-(1-propyl-1H-tetrazol-5-yl)cyclohexane-carboxamide収率 49%

実験手順

Employing 0.30 g (2.3 mmol) of cyclohexane carboxylic acid and 0.29 mg (2.3 mmol) of 1-propyl-1H-tetrazol-5-amine in the procedure described above and elution with CH2Cl2/MeOH/Et31NT (9.3:0.5:0.2) gave the product in 49% yield.

後処理

washelution with CH2Cl2/MeOH/Et31NT (9.3:0.5:0.2)
customgave the product in 49% yield

出典と根拠

ORDレコード: ord-05f62f9da28f40cbbbb6407600d95775
出典データセット: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08975288B2

反応ノート

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