Cyclopentanecarboxylic acid → N-(1-propyl-1H-tetrazol-5-yl)cyclopentane-carboxamide

反応式

[CH:1]1([C:6]([OH:8])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:9]([N:12]1[C:16]([NH2:17])=[N:15][N:14]=[N:13]1)[CH2:10][CH3:11]>>[CH2:9]([N:12]1[C:16]([NH:17][C:6]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:8])=[N:15][N:14]=[N:13]1)[CH2:10][CH3:11]

参加物

反応物 2

HCID 18840Cyclopentanecarboxylic acid

HCID 2206221-propyl-1H-tetrazol-5-amine

生成物 1

HCID 89855587N-(1-propyl-1H-tetrazol-5-yl)cyclopentane-carboxamide収率 45%

実験手順

Employing 0.30 g (2.6 mmol) of cyclopentane carboxylic acid and 0.33 mg (2.6 mmol) of 1-propyl-1H-tetrazol-5-amine in the procedure described above and elution with CH2Cl2/MeOH/Et3N (9.3:0.5:0.2) gave the product in 45% yield.

後処理

washelution with CH2Cl2/MeOH/Et3N (9.3:0.5:0.2)
customgave the product in 45% yield

出典と根拠

ORDレコード: ord-016b7303ec40435695338055668303a2
出典データセット: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08975288B2

反応ノート

読み込み中…

参加物