化工社化工社 化学情報印刷レポート · 研究参考用
Triphenylphosphine → HCID 58416760、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 4-Nitro-1-naphthol | HCID 343829 | — |
| 反応物 | (2-Aminopyridin-4-yl)methanol | HCID 1515296 | — |
| 反応物 | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 58416760 | HCID 58416760 | 56.3% |
反応手順
To a solution of 4-nitronaphthol (5.17 g, 27.3 mmol), PPh3 (10.75 g, 41.0 mmol) and 2-aminopyridine-4-methanol (1) (5.09 g, 41.0 mmol) in THF (50 mL) was added dropwise DIAD (8.07 mL, 41.0 mmol) at −15° C. The mixture was stirred overnight at RT and the volatiles removed in vacuo. The crude product was triturated from EtOAc (150 mL), filtered off and washed with EtOAc (100 mL). A second trituration from MeOH (100 mL) gave 2-amino-4-((4-nitronaphthalen-1-yloxy) methyl)pyridine (2) (4.54 g, 56%) as a yellow solid: m/z 296 (M+H)+ (ES+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08975285B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-d8d1cd533a6745e891573abf193f7bc9 |
| 出典メモ | uspto-grants-2015_03 |