関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,4-Cyclohexanediol | HCID 11162 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-(Chloromethyl)cyclohexene | HCID 556956 | — |
| 触媒 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(Cyclohex-3-enylmethoxy)cyclohexanol | HCID 66712793 | 61.8% |
反応手順
To toluene (500 g) were added 4-chloromethylcyclohexene (0.1 mol), 1,4-cyclohexanediol (0.5 mol), and tetrabutylammonium bromide (0.01 mol), the mixture was raised in temperature to 90° C., and a 5 N NaOH aqueous solution (100 g) was added dropwise thereto, followed by stirring for 5 hours. A toluene solution (toluene layer) was rinsed with water, concentrated, purified by silica gel chromatography, and thereby yielded 13 g of 4-(cyclohex-3-enylmethoxy)cyclohexanol with a purity of 99%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08975349B2 |
|---|
| 出典データセット | uspto-grants-2015_03 |
|---|
| ORD ID | ord-52ba03884f7147dc9dc7774e483934c1 |
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| 出典メモ | uspto-grants-2015_03 |
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