1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → HCID 67170874、化合物
反応式
[Cl:1][C:2]1[C:9]([F:10])=[C:8](I)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].O1CCCCC1[N:18]1[C:22](B2OC(C)(C)C(C)(C)O2)=[CH:21][CH:20]=[N:19]1>>[Cl:1][C:2]1[C:9]([F:10])=[C:8]([C:20]2[NH:19][N:18]=[CH:22][CH:21]=2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]参加物
3
実験手順
The title compound was prepared from 2-chloro-3-fluoro-4-iodobenzonitrile (0.242 g, 0.86 mmol) and 1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester (0.239 g, 0.86 mmol) using the method of Example 34 (a) and (b). Yield 0.075 g. 1H NMR (400 MHz; MeOD): δ 6.84 (dd, 1H), 7.59 (m, 2H), 7.79 (s, 1H), 8.08 (bs, 1H).
出典と根拠
- ORDレコード
- ord-fdf443ae7a6941ea881ec0d50df08337
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08975254B2
反応ノート
読み込み中…