化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → Modafinil acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Dimethyl Sulfate | HCID 6497 | — |
| 反応物 | Modafinil acid | HCID 3085267 | — |
| 反応物 | (-)-alpha-Methylbenzylamine (-)-benzhydrylsulphinyl acetate | HCID 68553371 | — |
| 生成物 | Modafinil acid | HCID 3085267 | — |
| 生成物 | HCID 178514057 | HCID 178514057 | — |
反応手順
The (−)-α-methylbenzylamine-(−)-benzhydrylsulphinyl acetate is then converted to (−)-benzhydrylsulphinylacetic acid by acid hydrolysis. The latter is esterified in the presence of dimethyl sulphate and then converted to amide in the presence of ammonia (gas). The (−) or l (laevorotatory) enantiomer of modafinil is obtained through this process with an overall yield of 5.7% in relation to the (±) modafinil acid, calculated on the basis of the yields corresponding to each stage.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08975442B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-121bbe4373a546a3896070a84e83898e |
| 出典メモ | uspto-grants-2015_03 |