Morpholine → 1-Morpholin-4-yl-[2,6]naphthyridine

HRID 8738ノート

反応式

HRID 8738 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][N:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[N:12]1([C:2]2[C:11]3[C:6](=[CH:7][N:8]=[CH:9][CH:10]=3)[CH:5]=[CH:4][N:3]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

参加物

3

反応物 2

HCID 8083MorpholineHCID 128847741-Chloro-2,6-naphthyridine

生成物 1

HCID 219836751-Morpholin-4-yl-[2,6]naphthyridine

実験手順

To 1-chloro-2,6-naphthyridine (164.3 mg, 0.998 mmol) (prepared as described in Van den Haak et al, J. Org. Chem 1982, 47 (9), 1673–7) was added morpholine (15 mL) and the mixture was heated at reflux for 4 h. Removal of the volatile components gave 216.6 mg of 1-morpholin-4-yl-[2,6]naphthyridine as a beige solid.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 4 h
  3. customRemoval of the volatile components

出典と根拠

ORDレコード
ord-617f60e42998408eb2d6587c55676ac9
出典データセット
uspto-grants-2006_08
特許番号
US07091200B2

反応ノート

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