Doxorubicin Hydrochloride → HCID 86598966、化合物

HRID 874086

反応式

HRID 874086 の反応式
[CH3:1][C@@H:2]1[O:7][C@@H:6]([O:8][C@@H:9]2[C:14]3=[C:15]([OH:32])[C:16]4[C:28](=[O:29])[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][C:26]=5[O:30][CH3:31])[C:20](=[O:21])[C:17]=4[C:18]([OH:19])=[C:13]3[CH2:12][C@@:11]([OH:37])([C:33]([CH2:35][OH:36])=[O:34])[CH2:10]2)[CH2:5][C@H:4]([NH2:38])[C@@H:3]1[OH:39].Cl.[S:41]([O-:45])([O-:44])(=[O:43])=[O:42].[NH4+].[NH4+]>>[CH3:1][C@@H:2]1[O:7][C@@H:6]([O:8][C@@H:9]2[C:14]3=[C:15]([OH:32])[C:16]4[C:28](=[O:29])[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][C:26]=5[O:30][CH3:31])[C:20](=[O:21])[C:17]=4[C:18]([OH:19])=[C:13]3[CH2:12][C@@:11]([OH:37])([C:33]([CH2:35][OH:36])=[O:34])[CH2:10]2)[CH2:5][C@H:4]([NH2:38])[C@@H:3]1[OH:39].[S:41]([O-:45])([O-:44])(=[O:43])=[O:42]

参加物

3

反応物 2

HCID 443939Doxorubicin Hydrochloride3 回HCID 6097028Ammonium Sulfate2 回

生成物 1

HCID 86598966HCID 86598966、化合物

実験手順

A preferred non-pegylated liposome of the present invention is loaded with doxorubicin hydrochloride and is prepared using methods described above. In one embodiment, when loading doxorubicin hydrochloride using the active loading procedure described above, the drug is dissolved in a suitable buffer solution (as described above) before loading to get a concentration of at least 25 mM. When the active loading process involves an ammonium sulfate gradient, the ammonium sulfate reacts with doxorubicin hydrochloride to form doxorubicin sulfate. Doxorubicin sulfate is insoluble and remains inside the liposomes after loading. Once any unentrapped or free drug is removed from loaded liposomes, the drug loaded liposomes are diluted using aqueous buffer solution to achieve the required drug concentration. The preferred buffer solution used is sucrose-histidine buffer solution as discussed previously.

後処理

  1. customis prepared
  2. dissolutionis dissolved in a suitable buffer solution (as described above)
  3. customto get a concentration of at least 25 mM

出典と根拠

ORDレコード
ord-896d61cbb7894948b4a509a66e7154cd
出典データセット
uspto-grants-2015_03
特許番号
US08980310B2

関連ノート

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