関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetal | HCID 7765 | — |
| 反応物 | Metformin Hydrochloride | HCID 14219 | — |
| 触媒 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 溶媒 | Isobutanol | HCID 6560 | — |
| 生成物 | 1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1) | HCID 10176486 | 77.6% |
反応手順
Comparative experiment) A mixture of 250.2 g of metformin hydrochloride, 213.6 g of acetaldehyde diethyl acetal and 12.5 g of toluene-4-sulfonic acid monohydrate in 500 ml of isobutanol was heated under reflux for 40 hours. Some of the solvent was removed by distillation. The mixture was cooled to 10° C., and the white precipitate was separated off, giving 224.7 g (77.4%) of 4-amino-3,6-dihydro-2-dimethylamino-6-methyl-1,3,5-triazine hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08980828B2 |
|---|
| 出典データセット | uspto-grants-2015_03 |
|---|
| ORD ID | ord-c879830670284ceba19d166f8c268531 |
|---|
| 出典メモ | uspto-grants-2015_03 |
|---|
