Ethyl[(pyridin-3-yl)methyl]amine → N-ethyl-N-(3-pyridinylmethyl)-2-(4-chlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetamide.hydrochloride

関与物質

反応手順

According to the method of Example 14, 2-(4-chlorophenyl)-7-methylimidazo[1,2-a]pyridine-3-acetic acid and N-(3-pyridinylmethyl)ethylamine were used as raw materials for synthesis, to obtain light yellow solid powder, yield 69.5%. m.p. 236-238° C., ESI-MS m/z: 420[M+H]+, 1H NMR(D2O, 400 MHz)δ: 0.95(t, 0.7H, J=7.00 Hz), 1.11(t, 2.3H, J=7.00 Hz), 2.39(s, 2.3H), 2.40(s, 0.7H), 3.27(q, 0.5H, J=7.00 Hz), 3.48(q, 1.5H, J=7.00 Hz), 4.13(s, 0.5H), 4.32(s, 1.5H), 4.60(s, 1.5H), 4.71(s, 0.5H), 7.15-7.22(m, 1H), 7.32-7.44(m, 4H), 7.51(s, 1H), 7.84(m, 1H), 8.12-8.14(m, 1H), 8.26(m, 1H), 8.52-8.53(m, 2H).

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