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Trimethylsilyldiazomethane → 1-N-Boc-4-Piperidinecarboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 反応物 | 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid | HCID 392871 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | 1-N-Boc-4-Piperidinecarboxylic acid methyl ester | HCID 392870 | 96.6% |
反応手順
To a solution of BOC-isonipecotic acid (45.0 g, 0.20 mol) dissolved in a 3:1 solution of dichloromethane/methanol (1200 mL) at 0° C. was added a solution of trimethylsilyldiazomethane (147 mL, 0.29 mol, 2.0M in hexane) over 30 min via an addition funnel. The reaction mixture was then concentrated to afford the title compound (47 g) as a light yellow oil. This was used directly in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091211B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-b2d23674e1954e95b0862e72fba9eb4a |
| 出典メモ | uspto-grants-2006_08 |