反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:6]=1[F:12])=O.[NH2:13][C:14]1[CH:15]=[C:16]([CH:21]=[CH:22][N:23]=1)[C:17]([O:19][CH3:20])=[O:18]>C(O)C>[F:12][C:6]1[CH:7]=[CH:8][C:9]([F:11])=[CH:10][C:5]=1[C:3]1[N:13]=[C:14]2[CH:15]=[C:16]([C:17]([O:19][CH3:20])=[O:18])[CH:21]=[CH:22][N:23]2[CH:2]=1参加物
反応条件
- 温度
- 60 °C
実験手順
2-Bromo-1-(2,5-difluorophenyl)ethanone (1.5 g) was added to an ethanol (8.2 ml) solution of methyl 2-aminoisonicotinate (1.0 g), and the obtained mixture was then stirred in a nitrogen atmosphere at 60° C. for 18 hours. Thereafter, 2-bromo-1-(2,5-difluorophenyl)ethanone (0.77 g) was added to the reaction solution, and the obtained mixture was then stirred for 6 hours at the same temperature as described above. Thereafter, the reaction solution was concentrated under reduced pressure, and ethyl acetate (10 ml) was then added to the obtained residue. The precipitated solid was collected by filtration, and it was washed with ethyl acetate (15 ml) and heptane (6 ml) and was then dried, so as to obtain the title compound (2.5 g) in the form of a pink solid.
後処理
- stirringthe obtained mixture was then stirred for 6 hours at the same temperature
- concentrationThereafter, the reaction solution was concentrated under reduced pressure, and ethyl acetate (10 ml)
- additionwas then added to the obtained residue
- filtrationThe precipitated solid was collected by filtration, and it
- washwas washed with ethyl acetate (15 ml) and heptane (6 ml)
- customwas then dried
出典と根拠
- ORDレコード
- ord-b35c6db733204e129668dc195af0bff4
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08980888B2
関連ノート
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