Dimethylformamide → 1-Bromo-4-((methylsulfonyl)methyl)benzene

HRID 874461ノート

反応式

HRID 874461 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.CN(C)C=O.[CH3:15][S:16]([O-:18])=[O:17].[Na+]>O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][S:16]([CH3:15])(=[O:18])=[O:17])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 685274-Bromobenzyl bromideHCID 2733271Sodium methanesulfinate

生成物 1

HCID 27614151-Bromo-4-((methylsulfonyl)methyl)benzene収率 95.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
65 °C

実験手順

A 250 mL round-bottomed flask was charged with 4-bromobenzyl bromide (5 g, 20 mmol) and N,N-dimethylformamide (10.81 mL). Sodium methanesulfinate (3.06 g, 30 mmol) was added. The reaction mixture was stirred at 65° C. for 1 hour. The reaction mixture was cooled to ambient temperature and diluted with water. The resulting suspension was stirred for 10 minutes and filtered. The solid was rinsed with water and dried under house vacuum over the weekend to provide 4.75 g (95%) of the title compound.

後処理

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. stirringThe resulting suspension was stirred for 10 minutes
  3. filtrationfiltered
  4. washThe solid was rinsed with water
  5. customdried under house vacuum over the weekend

出典と根拠

ORDレコード
ord-aadcf15d758546bbb4417297c61dfe81
出典データセット
uspto-grants-2015_03
特許番号
US08980879B2

反応ノート

読み込み中…