化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → (2-Fluorobiphenyl-4-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Fluorobiphenyl-4-carboxaldehyde | HCID 2759083 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (2-Fluorobiphenyl-4-yl)methanol | HCID 46314883 | 80% |
反応手順
2-Fluoro-biphenyl-4-carbaldehyde (1 gm, 5 mmole), NaBH4 were dissolved in ethanol stirred for 2 hrs, NaOH 10% was added, ethanol was evaporated, the reaction mixture was extracted with ethyl acetate, the ethyl acetate extract was dried with Na2SO4 and evaporated to produce white solid (0.8 gm, 80%). H1-NMR INOVA-500 (CDCl3) δ 2.266 (s, 1H), 4.683 (s, 2H), 7.142-7.168 (m, 2H), 7.339-7.442 (m, 4H), 7.519-7.535 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08980890B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-b9955eaf2d694eba973f6d69d19aedf5 |
| 出典メモ | uspto-grants-2015_03 |