Hydrochloric Acid → Benzyl 4-(2-amino-1-methoxycarbonylethyl)piperazine-1-carboxylate dihydrochloride

HRID 874570ノート

反応式

HRID 874570 の反応式
C(OC([NH:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])[CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:31].CO>C(O)(C)C>[ClH:31].[ClH:31].[NH2:8][CH2:9][CH:10]([N:15]1[CH2:16][CH2:17][N:18]([C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])[CH2:19][CH2:20]1)[C:11]([O:13][CH3:14])=[O:12]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 71115226benzyl 4-((S)-2-tert-butoxycarbonylamino-1-methoxycarbonylethyl)piperazine-1-carboxylate

生成物 1

HCID 86675018Benzyl 4-(2-amino-1-methoxycarbonylethyl)piperazine-1-carboxylate dihydrochloride収率 90%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
40 °C

実験手順

A solution of 1.45 g (3.4 mmol) of benzyl 4-((S)-2-tert-butoxycarbonylamino-1-methoxycarbonylethyl)piperazine-1-carboxylate in 3.5 ml of a solution of hydrochloric acid in isopropanol, having a concentration 5-6N, and 10 ml of methanol is heated at 40° C. for 3 h and then evaporated. The residue is taken up in diethyl ether and filtered. 1.2 g (90%) of benzyl 4-(2-amino-1-methoxycarbonylethyl)piperazine-1-carboxylate dihydrochloride are obtained in the form of a solid.

後処理

  1. customevaporated
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-485781ecdeb745289b528ac01b204165
出典データセット
uspto-grants-2015_03
特許番号
US08980897B2

反応ノート

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