Hydrochloric Acid → methyl (S)-3-amino-2-(4-ethylpiperazin-1-yl)propanoate trihydrochloride

HRID 874582

反応式

HRID 874582 の反応式
C(OC([NH:8][CH2:9][C@H:10]([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH3:22])[CH2:17][CH2:16]1)[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[ClH:23]>CO>[ClH:23].[ClH:23].[ClH:23].[NH2:8][CH2:9][C@H:10]([N:15]1[CH2:16][CH2:17][N:18]([CH2:21][CH3:22])[CH2:19][CH2:20]1)[C:11]([O:13][CH3:14])=[O:12]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86667916methyl (S)-3-tert-butoxycarbonylamino-2-(4-ethylpiperazin-1-yl)propanoate

生成物 1

HCID 86675024methyl (S)-3-amino-2-(4-ethylpiperazin-1-yl)propanoate trihydrochloride収率 54%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

2.5 g (7.9 mmol) of methyl (S)-3-tert-butoxycarbonylamino-2-(4-ethylpiperazin-1-yl)propanoate are placed in 20 ml of methanol and 10 ml of isopropanolic hydrochloric acid having a concentration of 5-6N. The reaction medium is heated at 40° C. for 3 h and then evaporated to dryness. The residue is taken up in 50 ml of ethanol, stirred for 1 h at ambient temperature and then filtered. 1.4 g (54%) of methyl (S)-3-amino-2-(4-ethylpiperazin-1-yl)propanoate trihydrochloride are obtained in the form of a beige solid.

後処理

  1. customevaporated to dryness
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-4f603e9752fa45fb810661ecf03927a6
出典データセット
uspto-grants-2015_03
特許番号
US08980897B2

関連ノート

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