関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,2-Dibromoethane | HCID 7839 | — |
| 反応物 | 2,5-Dibromophenol | HCID 34177 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 1,4-Dibromo-2-(2-bromoethoxy)benzene | HCID 11473835 | 51.4% |
反応手順
A mixture of 2,5-dibromophenol (134) (1.26 g, 5 mmol) and 1,2-dibromoethane (135) (431 μl, 5 mmol) in 5 ml 1N NaOH was stirred at 80° C. for 40 h. After cooling down, the reaction mixture was extracted with diethyl ether. Org. phase was washed with 1 N NaOH and brine subsequently. Org. phase was dried over sodium sulfate concentrated to give 922 mg (yield 51%, purity ca 90%) 1,4-dibromo-2-(2-bromoethoxy)benzene (136) as orange-red oil which was used directly for further reaction without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08980629B2 |
|---|
| 出典データセット | uspto-grants-2015_03 |
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| ORD ID | ord-3d97d962c25e40d3ab3e26eae504835e |
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| 出典メモ | uspto-grants-2015_03 |
|---|
