2-(Methylamino)ethanol → 4-Formyl-N-(2-hydroxyethyl)-N-methylbenzenesulfonamide
反応式
[CH3:1][NH:2][CH2:3][CH2:4][OH:5].C(N(CC)CC)C.[CH:13]([C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1)=[O:14]>C(Cl)Cl>[CH:13]([C:15]1[CH:16]=[CH:17][C:18]([S:21]([N:2]([CH2:3][CH2:4][OH:5])[CH3:1])(=[O:23])=[O:22])=[CH:19][CH:20]=1)=[O:14]参加物
5
実験手順
To an ice-cooled solution of 2-(methylamino)ethanol (0.196 mL, 2.44 mmol) and triethylamine (0.407 mL, 2.93 mmol) in DCM (10 mL) was added 4-formylbenzenesulfonyl chloride (0.500 g, 2.44 mmol). The reaction mixture was warmed slowly to RT and stirred at RT for 80 hours. The reaction mixture was diluted with DCM and was washed with 10% aqueous potassium hydrogen sulfate and dried (magnesium sulfate). The mixture filtered and the solvent evaporated at reduced pressure to afford the title compound (0.548 g, 92%).