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Trifluoroacetic acid → 2-[2-benzyloxy-1-(7H-pyrrolo[2,3-d]pyrimdin-4-ylamino)-ethyl]-5-methyl-3-phenyl-3H-quinazolin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | (2,5-Dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylmethoxypropanoate | HCID 333593 | — |
| 反応物 | Purine, 6-bromo- | HCID 5287830 | — |
| 反応物 | 7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- | HCID 5356682 | — |
| 反応物 | (2,5-Dioxopyrrolidin-1-yl) 2-(phenylmethoxycarbonylamino)butanoate | HCID 12961228 | — |
| 反応物 | HCID 178456854 | HCID 178456854 | — |
| 生成物 | 2-[2-benzyloxy-1-(7H-pyrrolo[2,3-d]pyrimdin-4-ylamino)-ethyl]-5-methyl-3-phenyl-3H-quinazolin-4-one | HCID 11591464 | — |
反応手順
Compound 30 was prepared using the general procedure described above with respect to compound 14, but 3-benzyloxy-2-tert-butoxycarbonylaminopropionic acid 2,5-dioxo-pyrrolidin-1-yl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidin-1-yl ester in step B, the alternate procedure (TFA deprotection) was used in step C, and 4-chloro-7H-pyrrolo[2,3-d]pyrimidine was substituted for 6-bromopurine in step D. MS (ES): m/z 503 (M+H), 395. Compound 30is shown below.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08980901B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-1ec3fd36bbb14d649a6859fe5dfb8976 |
| 出典メモ | uspto-grants-2015_03 |