関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Azanium;hydrate | HCID 22024077 | — |
| 反応物 | ethyl 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate | HCID 44232943 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | HCID 44235652 | 54% |
反応手順
1.0 g (2.6 mmol) of ethyl 8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate were dissolved in a mixture of 100 mL of methanol and 100 mL of ammonium hydrate 33%. The solution was stirred in a close bottle at 60° C. for 4 hours. The resulting precipitate was collected giving 0.5 g (54% yield) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08981089B2 |
|---|
| 出典データセット | uspto-grants-2015_03 |
|---|
| ORD ID | ord-45e05f07d797412d86ee341f8740cc17 |
|---|
| 出典メモ | uspto-grants-2015_03 |
|---|
