Hydrochloric Acid → HCID 86689368、化合物

HRID 875366ノート

反応式

HRID 875366 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24](/[CH:27]=[CH:28]/[C:29]3[CH:34]=[CH:33][C:32]([N:35](C(OC(C)(C)C)=O)[CH3:36])=[CH:31][CH:30]=3)=[CH:23][CH:22]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[ClH:44]>C(OCC)C>[ClH:44].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24](/[CH:27]=[CH:28]/[C:29]3[CH:34]=[CH:33][C:32]([NH:35][CH3:36])=[CH:31][CH:30]=3)=[CH:23][CH:22]=2)(=[O:9])=[O:10])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86689367HCID 86689367、化合物

生成物 1

HCID 86689368HCID 86689368、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

200 mg 2-[2-(2-{4-[(E)-2-{4-[(tert-butoxycarbonyl)(methyl)amino]phenyl}-vinyl]phenoxy}ethoxy)ethoxy]ethyl 4-methylbenzenesulfonate (2c) were dissolved in a 2M solution of HCl in diethyl ether. The mixture was stirred at room temperature for 72 h. The solvent was removed under reduced pressure. Diethyl ether was added and the precipitate was collected, washed with diethyl ether and dried under reduced pressure. 160 mg 2e were obtained as light yellow solid.

後処理

  1. customThe solvent was removed under reduced pressure
  2. additionDiethyl ether was added
  3. customthe precipitate was collected
  4. washwashed with diethyl ether
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-b9be0a7d2b934ec4b615fdcf08d2ef15
出典データセット
uspto-grants-2015_03
特許番号
US08981156B2

反応ノート

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