Acetic Anhydride → N-(4-methyl-5-nitropyridin-2-yl)acetamide

HRID 875381

反応式

HRID 875381 の反応式
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH2:11])[CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH:11][C:12](=[O:14])[CH3:13])[CH:3]=1

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 2431652-Amino-4-methyl-5-nitropyridine

生成物 1

HCID 13567013N-(4-methyl-5-nitropyridin-2-yl)acetamide収率 87%

反応条件

温度
90 °C

実験手順

A mixture of 4-methyl-5-nitropyridin-2-amine (5 g, 32 mmol) and acetic anhydride (20 mL) was heated at 90° C. for 4 hours. After cooling the solvent was evaporated under vacuum. The concentrated mass was dissolved in toluene and evaporated under vacuum. The resulting solid was triturated with diethyl ether and filtered to afford N-(4-methyl-5-nitropyridin-2-yl) acetamide (5.5 g, 87%).

後処理

  1. temperatureAfter cooling the solvent
  2. customwas evaporated under vacuum
  3. dissolutionThe concentrated mass was dissolved in toluene
  4. customevaporated under vacuum
  5. customThe resulting solid was triturated with diethyl ether
  6. filtrationfiltered

出典と根拠

ORDレコード
ord-d06bd54f5f924e2ebe9150a2b1d7623e
出典データセット
uspto-grants-2015_03
特許番号
US08980911B2

関連ノート

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