化工社化工社 化学情報印刷レポート · 研究参考用
P-Anisidine → N4-Adamant-1-yl-N6-(4-methoxyphenyl)pyrimidine-4,6-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | P-Anisidine | HCID 7732 | — |
| 反応物 | Binap, (A+-)- | HCID 634876 | — |
| 反応物 | 6-chloro-N-(1-Adamantyl)pyrimidin-4-amine | HCID 53486071 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N4-Adamant-1-yl-N6-(4-methoxyphenyl)pyrimidine-4,6-diamine | HCID 70941076 | 65% |
反応手順
100 mg of N-adamant-1-yl-6-chloropyrimidin-4-amine, 56 mg of p-anisidine, 73 mg of Na-butylate, 2.2 mg of Pd(OAc)2 and 12 mg of BINAP were taken in a screw cap vial under agron in 4 mL of dry toluene and the vial was kept in a heating block at 150° C. for 12 hours. The mixture obtained was cooled to r.t. and purification was carried out by column chromatography using PE:EtOAc 2:1. N4-Adamant-1-yl-N6-(4-methoxyphenyl)pyrimidine-4,6-diamine was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08986994B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-c8eea45fbae14fdb81a3532519effe2e |
| 出典メモ | uspto-grants-2015_03 |