Diethyl Ether → HCID 90413778、化合物
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](O)=[O:10])=[CH:4][C:3]=1[Br:12].C[Si]([CH:17]=[N+:18]=[N-])(C)C.C(OCC)C>CO.ClCCl>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:18][CH3:17])=[O:10])=[CH:4][C:3]=1[Br:12]参加物
6
実験手順
To 2-(4-amino-3-bromo-phenyl)acetic acid (5 g, 21.73 mmol) in methanol (50 mL) and dichlormethane (100 mL) is added at −5° C. trimethylsilyldiazomethane in diethylether 2 mol/L (31.51 mL, 63.03 mmol) dropwise over a period of 30 min. The reaction mixture is allowed to warm up to r.t. and concentrated. The crude product is used without further purification.
後処理
- concentrationconcentrated
- customThe crude product is used without further purification
出典と根拠
- ORDレコード
- ord-79de351fc1e9405fb5426db625d9bd33
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987249B2
反応ノート
読み込み中…