N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide → N-{5-[3-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide

HRID 876245ノート

反応式

HRID 876245 の反応式
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:12]=[N:13][CH:14]=2)[CH:6]=[CH:7][CH:8]=1>C(O)(=O)C>[F:24][C:2]([F:1])([F:25])[C:3]1[CH:4]=[C:5]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([NH:15][C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:23])[CH2:10]2)[CH:6]=[CH:7][CH:8]=1

参加物

3

反応物 1

HCID 66701292N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide

生成物 1

HCID 66701267N-{5-[3-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 840 mg (1.82 mmol) of N-{5-[3-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide in 100 ml of glacial acetic acid was reacted according to General Method 6A. The solution was concentrated under reduced pressure. The product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 700 mg

後処理

  1. concentrationThe solution was concentrated under reduced pressure
  2. customThe product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient)

出典と根拠

ORDレコード
ord-31b0e3a16f834997a2d8c9fbf8810897
出典データセット
uspto-grants-2015_03
特許番号
US08987248B2

反応ノート

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