反応式
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:12]=[N:13][CH:14]=2)=[CH:5][CH:4]=1>C(O)(=O)C>[F:24][C:2]([F:1])([F:25])[C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([NH:15][C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:23])[CH2:10]2)=[CH:7][CH:8]=1参加物
3
実験手順
A solution of 1.0 g (2.9 mmol) of N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide in 120 ml of glacial acetic acid was reacted according to General Method 6A. The solution was concentrated under reduced pressure. The product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 657 mg (50% pure).
後処理
- concentrationThe solution was concentrated under reduced pressure
- customThe product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient)
出典と根拠
- ORDレコード
- ord-2e9c2f26daaf444dabbf4bcb30935231
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987248B2
関連ノート
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