Cyclopropaneacetic acid → 1-(Cyclopropylacetyl)-5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide

反応式

[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([C:15]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:16])[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[CH:24]1([CH2:27][C:28](O)=[O:29])[CH2:26][CH2:25]1>>[CH:24]1([CH2:27][C:28]([N:13]2[CH2:14][CH:9]([C:6]3[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][CH:7]=3)[CH2:10][CH:11]([C:15]([NH:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)=[O:16])[CH2:12]2)=[O:29])[CH2:26][CH2:25]1

参加物

反応物 2

HCID 138440Cyclopropaneacetic acid

HCID 667015535-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide

生成物 1

HCID 469313071-(Cyclopropylacetyl)-5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide

実験手順

68 mg (0.20 mmol) of 5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide (Example 17A) and 22 mg (0.22 mmol, 1.1 eq.) of cyclopropylacetic acid were reacted according to General Method 1.

出典と根拠

ORDレコード: ord-fbfec7d8c3ef425791c0ff27c3291169
出典データセット: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08987248B2

反応ノート

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