3-Methoxypropanoyl chloride → 5-(4-ethylphenyl)-1-(3-methoxypropanoyl)-N-phenylpiperidine-3-carboxamide

HRID 876268ノート

反応式

HRID 876268 の反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([C:15]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:16])[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[CH3:24][O:25][CH2:26][CH2:27][C:28](Cl)=[O:29]>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:14][N:13]([C:28](=[O:29])[CH2:27][CH2:26][O:25][CH3:24])[CH2:12][CH:11]([C:15]([NH:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)=[O:16])[CH2:10]2)=[CH:7][CH:8]=1)[CH3:2]

参加物

3

反応物 2

HCID 27597283-Methoxypropanoyl chlorideHCID 667015535-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide

生成物 1

HCID 667607595-(4-ethylphenyl)-1-(3-methoxypropanoyl)-N-phenylpiperidine-3-carboxamide

実験手順

62 mg (0.18 mmol) of 5-(4-ethylphenyl)-N-phenylpiperidine-3-carboxamide (Example 17A) and 33 mg (0.27 mmol, 1.5 eq.) of methoxypropionyl chloride were reacted according to General Method 2. Yield: 65 mg (91% of theory)

出典と根拠

ORDレコード
ord-65a47e3107dd445ab8d4b987a9a12574
出典データセット
uspto-grants-2015_03
特許番号
US08987248B2

反応ノート

読み込み中…