Hydrochloric Acid → N-{1-[(4-Aminotetrahydro-2H-pyran-4-yl)carbonyl]-5-(3,4-dimethylphenyl)piperidin-3-yl}benzenecarboxamide hydrochloride
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][CH:13]([NH:15][C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:17])[CH2:12][N:11]([C:24]([C:26]3([NH:32]C(=O)OC(C)(C)C)[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[O:25])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8].[ClH:40]>O1CCOCC1>[ClH:40].[NH2:32][C:26]1([C:24]([N:11]2[CH2:10][CH:9]([C:4]3[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([CH3:1])[CH:3]=3)[CH2:14][CH:13]([NH:15][C:16]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)=[O:17])[CH2:12]2)=[O:25])[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
33 mg (0.06 mmol) of tert-butyl [4-({3-(3,4-dimethylphenyl)-5-[(phenylcarbonyl)amino]piperidin-1-yl}carbonyl)tetrahydro-2H-pyran-4-yl]carbamate were dissolved in 4 ml of dioxane, 1 ml of concentrated hydrochloric acid was added and the mixture was immediately concentrated on a rotary evaporator. The residue was then purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 15 mg (57% of theory)