Potassium Carbonate → N-{1-[(1,1-Dioxidothiomorpholin-4-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}-benzenecarboxamide

関与物質

反応手順

200 mg (0.39 mmol) of 4-nitrophenyl 3-[(phenylcarbonyl)amino]-5-[4-(trifluoromethyl)phenyl]piperidine-1-carboxylate were initially charged in 4.3 ml of DMF, and 158 mg (1.17 mmol) of thiomorpholine 1,1-dioxide and 54 mg (0.39 mmol) of potassium carbonate were added. The mixture was reacted in a microwave (Emrys Optimizer) at 150° C. for 15 min. The crude product was then purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient).

情報源と証拠