3-(Tert-butoxycarbonylamino)-2,2-dimethylpropyl methanesulfonate → 3-(2-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-yloxy)-2,2-dimethylpropan-1-amine
反応式
CS([O:5][CH2:6][C:7]([CH3:18])([CH3:17])[CH2:8][NH:9]C(OC(C)(C)C)=O)(=O)=O.[N:19]1[N:20]=[C:21]([C:28]2[CH:37]=[CH:36][C:35]3[C:30](=[C:31](O)[CH:32]=[C:33]([F:38])[CH:34]=3)[N:29]=2)[N:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=12>>[N:19]1[N:20]=[C:21]([C:28]2[CH:37]=[CH:36][C:35]3[C:30](=[C:31]([O:5][CH2:6][C:7]([CH3:17])([CH3:18])[CH2:8][NH2:9])[CH:32]=[C:33]([F:38])[CH:34]=3)[N:29]=2)[N:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=12参加物
3
実験手順
The desired product was prepared as described in Example 25 using 3-(tert-butoxycarbonylamino)-2,2-dimethylpropyl methanesulfonate in place of (cis)-tert-butyl-3-fluoro-4-(methylsulfonyloxy)piperidine-1-carboxylate, and 2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-ol in place of 2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-ol. MS ESI (+) m/z 366 (M+1) detected.
出典と根拠
- ORDレコード
- ord-77b156aff74d4b768d51e8f4d2e4a638
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987251B2
反応ノート
読み込み中…