tert-butyl N-(3-hydroxy-2,2-dimethylpropyl)carbamate → Tert-butyl 3-(2-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yloxy)-2,2-dimethylpropylcarbamate
反応式
[OH:1][CH2:2][C:3]([CH3:14])([CH3:13])[CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9].[Br:15][C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]3[CH:34]=[CH:33][C:32]4[C:27](=[C:28](O)[CH:29]=[CH:30][CH:31]=4)[N:26]=3)=[N:23][N:24]=2)[CH:21]=1>>[Br:15][C:16]1[CH:17]=[CH:18][C:19]2[N:20]([C:22]([C:25]3[CH:34]=[CH:33][C:32]4[C:27](=[C:28]([O:1][CH2:2][C:3]([CH3:14])([CH3:13])[CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:9])([CH3:11])[CH3:10])[CH:29]=[CH:30][CH:31]=4)[N:26]=3)=[N:23][N:24]=2)[CH:21]=1参加物
3
実験手順
Prepared as described in Example 9, Step A, using tert-butyl 3-hydroxy-2,2-dimethylpropylcarbamate in place of tert-butyl-4-hydroxypiperidine-1-carboxylate and 2-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-ol in place of 2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-ol.
後処理
- customPrepared