Dichloromethane → 4-oxo-2-(3-(trifluoromethyl)phenyl)-4H-chromene-8-carbonyl chloride

HRID 876539ノート

反応式

HRID 876539 の反応式
[O:1]=[C:2]1[C:11]2[C:6](=[C:7]([C:12](O)=[O:13])[CH:8]=[CH:9][CH:10]=2)[O:5][C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)=[CH:3]1.C(Cl)[Cl:26]>CN(C=O)C>[O:1]=[C:2]1[C:11]2[C:6](=[C:7]([C:12]([Cl:26])=[O:13])[CH:8]=[CH:9][CH:10]=2)[O:5][C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)=[CH:3]1

参加物

4

反応物 2

HCID 6344DichloromethaneHCID 584772184-oxo-2-(3-(trifluoromethyl)phenyl)-4H-chromene-8-carboxylic acid

生成物 1

HCID 584773264-oxo-2-(3-(trifluoromethyl)phenyl)-4H-chromene-8-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide触媒

実験手順

Oxallylchloride (285 mg, 2.24 mmol) was added to a solution of 4-oxo-2-(3-(trifluoromethyl)phenyl)-4H-chromene-8-carboxylic acid 35 (250 mg, 0.75 mmol) in CH2Cl2 (15 mL) followed by DMF (1 drop). The reaction mixture was stirred at room temperature for 12 h. The volatiles were concentrated and the crude residue was dissolved in CH2Cl2. The solvent was evaporated and the crude product dried under vacuum and used without further purification.

後処理

  1. concentrationThe volatiles were concentrated
  2. dissolutionthe crude residue was dissolved in CH2Cl2
  3. customThe solvent was evaporated
  4. dry with materialthe crude product dried under vacuum
  5. customused without further purification

出典と根拠

ORDレコード
ord-17e866f8e7e24da5a0f376f298a27f3e
出典データセット
uspto-grants-2015_03
特許番号
US08987258B2

反応ノート

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