Hydrochloric Acid → 4-bromo-1H-indazole

HRID 876563

反応式

HRID 876563 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][N:6]2C(=O)C.Cl>CO>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 454801851-Acetyl-4-bromo-1H-indazole

生成物 1

HCID 223525484-bromo-1H-indazole収率 93%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of the 1-(4-bromo-indazol-1-yl)-ethanone (3.09 g, 12.9 mmol) in MeOH (50 mL) was added 6N aqueous HCl (30 mL) and the mixture was stirred at room temperature for 7 h. The MeOH was evaporated and the mixture partitioned between EtOAc (2×50 mL) and water (50 mL). The combined organic layers were washed with brine (50 mL), separated and dried (MgSO4). The solvent was removed by evaporation under reduced pressure to give 4-bromo-1H-indazole (2.36 g, 93%).

後処理

  1. customThe MeOH was evaporated
  2. customthe mixture partitioned between EtOAc (2×50 mL) and water (50 mL)
  3. washThe combined organic layers were washed with brine (50 mL)
  4. customseparated
  5. dry with materialdried (MgSO4)
  6. customThe solvent was removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-ba6f684c3a0c42d89368aa7473db13d0
出典データセット
uspto-grants-2015_03
特許番号
US08987260B2

関連ノート

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