Dimethylformamide diethylacetal → 3-(Dimethylamino)-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]acrylic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][N:6]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[N:8]=[CH:7]1)[CH3:2].C(O[CH:19](OCC)[N:20]([CH3:22])[CH3:21])C>>[CH2:1]([O:3][C:4](=[O:15])[C:5]([N:6]1[CH:10]=[C:9]([C:11]([F:14])([F:12])[F:13])[N:8]=[CH:7]1)=[CH:19][N:20]([CH3:22])[CH3:21])[CH3:2]参加物
3
実験手順
38.0 g (170.8 mmol) of the compound from Example 32A and 58.5 ml (50.3 g, 341.6 mmol) dimethylformamide diethyl acetal are stirred at a bath temperature of 100° C. for 16 h. For working up, the cooled reaction solution is concentrated on a rotary evaporator and the residue is dried in vacuo.
後処理
- customthe cooled reaction solution
- concentrationis concentrated on a rotary evaporator
- customthe residue is dried in vacuo
出典と根拠
- ORDレコード
- ord-e36c94ea1d98478b9a91bde91568c25c
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987261B2
反応ノート
読み込み中…