Hydrochloric Acid → Thieno[3,2-c]pyridine-2-carboxylic acid

HRID 876769ノート

反応式

HRID 876769 の反応式
[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10]([O:12]C)=[O:11].O[Li].O.Cl>CO.O>[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10]([OH:12])=[O:11]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 22047666Methyl thieno[3,2-c]pyridine-2-carboxylate

生成物 1

HCID 13580293Thieno[3,2-c]pyridine-2-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of methyl thieno[3,2-c]pyridine-2-carboxylate (D-2) (12 g, 62.1 mmol) in MeOH (150 mL) and H2O (15 mL) was added LiOH.H2O (5.2 g, 124.2 mmol). The solution was stirred at room temperature overnight, and then acidified with 1N aqueous HCl. The resulting white precipitate was collected by filtration and air-dried to afford the title compound. MS (m/z): 179 (M)+.

後処理

  1. filtrationThe resulting white precipitate was collected by filtration
  2. customair-dried

出典と根拠

ORDレコード
ord-90be16a73ab14217a01601673cc6a8d7
出典データセット
uspto-grants-2015_03
特許番号
US08987269B2

反応ノート

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