Ethanol → HCID 67305656、化合物

HRID 876786ノート

反応式

HRID 876786 の反応式
[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([C:10]#[N:11])=[CH:2]1.CCO>N.[Ni]>[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH2:10][NH2:11])=[CH:2]1

参加物

5

反応物 2

HCID 702EthanolHCID 21828305Thieno[2,3-b]pyridine-3-carbonitrile

生成物 1

HCID 67305656HCID 67305656、化合物

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 222Ammonia溶媒

実験手順

To a solution of thieno[2,3-b]pyridine-3-carbonitrile (J-4) (320 mg, 2 mmol) in NH3.EtOH (25 mL) was added Ranye/Ni (about 300 mg). The reaction was degassed with hydrogen and stirred at room temperature for 2 h. Then the mixture was filtered, and the filtrate was concentrated to give the title compound, which was used for next step without purification. MS (m/z): 165 (M+1)+.

後処理

  1. customThe reaction was degassed with hydrogen
  2. filtrationThen the mixture was filtered
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-016509b0dd284250a9613f2e44b35017
出典データセット
uspto-grants-2015_03
特許番号
US08987269B2

反応ノート

読み込み中…