化工社化工社 化学情報印刷レポート · 研究参考用
Oxalyl chloride → Quinoline-6-carbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 6-Quinolinecarboxylic acid | HCID 82571 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Quinoline-6-carbonyl chloride | HCID 12391963 | 99.8% |
反応手順
To a mixture of quinoline-6-carboxylic acid (0-1) (2.0 g, 11.5 mmol) in CH2Cl2 (250 mL) was added 3 drops of DMF at 0° C., followed by oxalyl chloride (7.3 g, 57.5 mmol) dropwise. The resulting reaction was stirred at room temperature overnight, and then concentrated to afford the title compound (2.2 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08987269B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-a32c4c7516d54483ba9baf7d0922695d |
| 出典メモ | uspto-grants-2015_03 |