関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Trifluoroacetic anhydride | HCID 9845 | — |
| 反応物 | Quinoline-6-carboxamide | HCID 11052097 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Quinoline-6-carbonitrile | HCID 592995 | 90.1% |
反応手順
To a mixture of quinoline-6-carboxamide (0-3) (1.2 g, 7.2 mmol) and triethylamine (2.2 g, 21.8 mmol) in DCM (50 mL) at 0° C. was added trifluoroacetic acid anhydride (1.9 g, 8.9 mmol). The reaction was stirred for 10 mins at 0° C., then quenched with water. The resulting mixture was extracted with DCM. The organic layer was dried over anhydrous Na2SO4, and concentrated to afford the desired title compound (1.0 g). MS (m/z): 154 (M)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08987269B2 |
|---|
| 出典データセット | uspto-grants-2015_03 |
|---|
| ORD ID | ord-afe968d3ef0340db91325a91e1947b50 |
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| 出典メモ | uspto-grants-2015_03 |
|---|
