2-(Bromomethyl)thiazolo[5,4-b]pyridine → Thiazolo[5,4-b]pyridin-2-ylmethanamine

反応式

Br[CH2:2][C:3]1[S:4][C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][N:6]=2.S1C2C(=[N:16]C=CC=2)C=C1CN>>[N:11]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[S:4][C:3]=1[CH2:2][NH2:16]

参加物

反応物 2

HCID 673051492-(Bromomethyl)thiazolo[5,4-b]pyridine

HCID 67305714Thieno[3,2-b]pyridin-2-ylmethanamine

生成物 1

HCID 64983126Thiazolo[5,4-b]pyridin-2-ylmethanamine

実験手順

Intermediate S was prepared from 2-(bromomethyl)thiazolo[5,4-b]pyridine (S-4) following similar procedured for synthesizing intermediate C from C-5, as described above. MS (m/z): 166 (M+1)+.

出典と根拠

ORDレコード: ord-364c3d8c46064cdaa02737ace0f09965
出典データセット: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08987269B2

反応ノート

読み込み中…